Needless to say, I don't take that stuff anymore. But then they won't do a damn thing unless I wait several days before I take anymore.I could take a quadruple dose on day 2 (not all at once) and it won't even make me drowsy. A single dose does nothing, so I take a double dose and it works. And these are all types of drugs I take VERY VERY rarely, from maybe once a week to once a month, or even less. Pretty much ANY medication I have to double or even triple dose for it to have any effect where the "average" person only needs a single dose. Even OTC stuff like aspirin, Unisom (or any sleeping pill), motrin, Or things like muscle relaxers like Flexaril, Soma (which no longer take because it started giving my migraines) Valium, etc. The metabolize part is something I think that really messes me up with ANY drugs. Maybe it can help you, along with the genetic test for exploring your metabolism, can help you convince your doctor to rotate your opiates. Perhaps you're taking the wrong drug? Here's a paper that describes opioid metabolism in detail. There are now tests available allowing doctors to match opioid therapy to a patient's metabolic capacity. Altered metabolism in a patient or population can result in an opioid or metabolite leaving the body too rapidly, not reaching its therapeutic level, or staying in the body too long and producing toxic effects. An individual's genetics determines his/her ability to manufacture CYP and UGT enzymes meaning that we don't all metabolize any medication equally. Phase II metabolism is based on another enzyme, UGT. The metabolism of hydrocodone occurs in two phases - an aggressive phase I involves cytochrome P450 (CYP) enzymes. At the dentist, I need a double or triple dose of marcaine to numb my gum and jaw. My wife takes 1/2 and sometimes 1/4 of a pill and she sleeps like a baby. I take one pill at bedtime, and often I'm up in 2-3 hours later and sometimes take a second pill. My wife and I both use the same sleeping pill. There are many people who require more medication than others. I really think the DEA or some gov agency has been putting some pressure on him. But yesterday he seemed REALLY stressed out. Back when I worked in IT, we used to talk about computers like two buddies talking about sports over a few beers. But if I do get into see a pain specialist, they will probably know how to treat me better than my GP. I haven't looked into the validity of that, but I trust she knew what she was talking about. And according to my Doctors PA (Who I saw after my last MRI) that nothing could be done about the Schmorl's nodes. I would rather just get it fixed and never have to take another pill again. But he did say that he was going to try to find me a local pain specialist that takes Medicaid. Was at the doc yesterday and he told me after the first of the year, he will no longer be prescribing opiates/narcotics other than tylenol/codeine to ANY of his patients.
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